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Hey - Chord 4 is definitely spaced the best, and will therefore sound the strongest. As well as making the bass more prominent and clear, the whole chord will sound better than the others because all the lower parts are widely spaced. It's always better to keep the bass widely spaced and have any small intervals in the upper voices. One very important thing though, is that you don't double the third of the chord more than once - which is why nos.1 and 2 would sound very bad in context.
It puts a heavy and uncomfortable emphasis on the leading note, and will inevitable lead to consecutive octaves (the kind that you don't want)!
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